Table 3 Results from conditional analyses at previously reported smoking behaviour loci

From: Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Gene region

dbSNP ID

Chr:Pos

EA/OA

Consequence

Trait

EAF

P (unconditional)

SNV(s) conditioned on

Discovery Conditional P [DoE]

Conditional P in replication [DoE]

19q13 (RAB4B)

rs8102683

19:41363765

C/T

Intergenic

CPD

74.8%

4.53 × 10−16

rs7937

1.44 × 10−13 [+]

3.5 × 10-4 [+]

 

rs28399442

19:41354458

A/C

Intronic (CYP2A6)

CPD

1.3%

2.27 × 10−12

rs7937, rs8102683

2.63 × 10−12 [+]

8.1 × 10−14 [+]

 

rs3865453

19:41338556

T/C

Intergenic

CPD

6.54%

2.96 × 10−12

rs7937, rs8102683, rs28399442

4.96 × 10−10 [−]

2.3 × 10−13 [−]

TEX41-PABPC1P2

rs11694518

2:146125523

T/C

Intergenic

SI

29.5%

2.90 × 10−9

rs10193706

3.43 × 10−7 [−]

4.0 × 10−31 [−]

15q25 (CHRNA3)

rs938682

15:78882925

A/G

Intronic (CHRNA3)

CPD

76.4%

1.83 × 10−69

rs1051730

7.77 × 10−21 [+]

1.0 × 10−13 [+]

  1. SNVs with P < 5 × 10−8 are highlighted in bold. The discovery sample size for smoking initiation (SI) and CPD was 346,813 and 128,746, respectively. The replication sample size for SI and CPD were 275,596 and 80,015, respectively. Chr Chromosome, Pos position for hg19 build 37, EA effect allele, OA other allele, EAF effect allele frequency in the pooled samples, DoE Direction of effect
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