Table 2 Results from polygenic risk score analysis using UK Biobank GWAS summary statistics as discovery and testing aggregate genetic risk between BioVU patients having chart reviewed suicide attempt (left side) and quantitative probability of suicide attempt (right side) using logistic and linear regression, respectively

From: Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide

   

Suicide attempt

Predicted risk of suicide attempt

Sample

N

Validated attempt

Est

SE

T

P

Est

SE

T

P

MEGA

18,128

40

22.0

9.2

2.41

0.016

893.7

202.2

4.42

9.96 × 10−6

660

2,965

17

−16.2

31.4

−0.52

0.607

491.7

424.5

1.16

0.247

Omni1M

3,453

16

33.9

24.0

1.41

0.157

44.2

375.9

0.12

0.906

Total

24,546

73

18.39

8.60

2.14

0.033

659.9

164.0

4.02

5.75 × 10−5

  1. Est regression estimate, SE standard error, T regression t-statistic, P p-value
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