Fig. 1 | Molecular Psychiatry

Fig. 1

From: Sex-dependent neurobiological features of prenatal immune activation via TLR7

Fig. 1

Prenatal TLR7 activation induces a maternal inflammatory response and induces a male bias in litters. a Experiment design showing different behavioral and physiological tests performed and the age as embryonic day (E), post-natal day (PND), or post-natal week (PNW). Experiment was run in three major cohorts denoted as subscript 1, 2, or 3. Induction of (b) IL-6 and (c) IFNα in maternal serum 3 h following last injection of IMQ on E16. d Prenatal IMQ led to a significant male bias in sex ratio of litters. Prenatal IMQ did not induce ANAs in (e) mothers or (f) offspring. *P < 0.05, **P < 0.01, mean ± SEM

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