Fig. 1

Experimental design. Dhcr7+/− female mice were mated with wild-type (WT) males and Dhcr7+/− male mice were mated with WT female mice (a). Pregnant mice were injected with either vehicle or 5 mg/kg aripiprazole from E12 to E19. At P0, pups were sacrificed and their brain sterol profile was analyzed. b denotes a typical liquid chromatography tandem mass spectrometric chromatogram denoting cholesterol, 7-dehydrocholesterol, and their respective internal standards