Fig. 2 | Molecular Psychiatry

Fig. 2

From: Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Fig. 2

Aripiprazole (ARI) and its metabolites cross the placental barrier. ARI and its metabolites were readily detectable in the brain of newborn pups. A positive correlation between ARI and dehydroaripiprazole (a) and 2,3-dichlorophenylpiperazine (b) was observed in the analyzed tissue. Only ARI-treated pup data are disclosed, as in vehicle-treated pup brains no ARI or metabolites were detected. Each symbol denotes ARI level in a single ARI-treated brain sample (n = 19), filled symbols denote pups with a Dhcr7+/+ genotype (wild type), open symbols denote pups with a Dhcr7+/− genotype. Pearson correlation coefficients (r2 and p values) were calculated using GraphPad Prism 7

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