Fig. 4 | Molecular Psychiatry

Fig. 4

From: Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Fig. 4

7-Dehydrocholesterol (7-DHC) levels found in the brain of P0 pups exposed to vehicle or aripiprazole (5 mg/kg). 7-DHC levels (a) and 7-DHC/cholesterol ratio (b) are grouped taking into account all the three variables: maternal genotype, embryonic genotype, and drug treatment (three-way analysis). Black and gray columns denote wild-type and Dhcr7+/− pups, respectively. The mothers’ genotypes are depicted above the graph. Values correspond to the mean ± SEM. Note that the 7-DHC levels are the highest in Dhcr7+/− pups from Dhcr7+/− mothers, indicating a synergism between maternal genotype×embryonic genotype×treatment. Comprehensive statistical analysis of data is presented in Table 2

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