Fig. 5
7-Dehydrocholesterol (7-DHC)/cholesterol ratio in the brain of P0 pups exposed to vehicle or aripiprazole (ARI; 5 mg/kg). a shows changes in 7-DHC/cholesterol in the context of the maternal genotype. Both wild-type (WT) and Dhcr7+/− pups were grouped taking into account only their mothers’ genotype. b shows changes in 7-DHC/cholesterol in the context of the embryonic genotype. Pups were grouped taking into account only their own genotypes, regardless if they were born from WT or Dhcr7+/− mothers. 7-DHC/cholesterol ratio is increased as a result of ARI injection and it is dependent on the maternal (a) and embryonic genotypes (b). Values were normalized against the control condition (i.e. WT-Vehicle = 1). The genotypes are depicted below the groups. Statistical significance: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Bars correspond to the mean ± SEM. Each symbol corresponds to a single pup. Note that the 7-DHC/cholesterol ratio in Dhcr7+/− pups is elevated compared to their WT littermates (b). This difference is enhanced in the ARI-injected group, highlighting increased vulnerability of Dhcr7+/− to ARI’s side effects. The raw sterol ratio values are reported in supporting information
