Table 4 New drug discovery/repurposing leads
From: Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs
A. CMAP analysis with nominally validated biomarkers (22 increased and 118 decreased were present in HG-U133A array used by Connectivity Map) | ||
|---|---|---|
Rank | cmap name | Score |
6100 | cefotiam | −1 |
6099 | proguanil | −0.991 |
6098 | hydroxyachillin | −0.96 |
6097 | Prestwick-682 | −0.95 |
6096 | levopropoxyphene | −0.949 |
6095 | isoflupredone | −0.943 |
6094 | ozagrel | −0.941 |
6093 | streptozocin | −0.938 |
6092 | cyclopenthiazide | −0.934 |
6091 | metformin | −0.93 |
6090 | corticosterone | −0.925 |
6089 | calcium folinate | −0.924 |
6088 | diphenhydramine | −0.921 |
B. CMAP analysis with biomarkers that are nominally predictive in all (5 increased and 52 decreased were present in HG-U133A array used by Connectivity Map) | ||
|---|---|---|
Rank | cmap name | Score |
6100 | ambroxol | −1 |
6099 | ozagrel | –0.971 |
6098 | cefotiam | −0.959 |
6097 | xamoterol | −0.951 |
6096 | betulin | −0.93 |
6095 | isometheptene | −0.927 |
6094 | primidone | −0.925 |
6092 | tocainide | −0.919 |
6093 | diloxanide | −0.919 |
6089 | alprostadil | −0.913 |
6090 | amphotericin B | −0.913 |
6087 | oxolamine | −0.909 |
C. CMAP analysis with biomarkers that are nominally predictive in males (5 increased and 48 decreased were present in HG-U133A array used by Connectivity Map) | ||
|---|---|---|
Rank | cmap name | Score |
6100 | ozagrel | −1 |
6099 | flucloxacillin | −0.981 |
6098 | ambroxol | −0.97 |
6097 | dapsone | −0.958 |
6096 | tiaprofenic acid | −0.955 |
6095 | primidone | −0.939 |
6094 | betulin | −0.936 |
6093 | proguanil | −0.929 |
6092 | gossypol | −0.925 |
6091 | levopropoxyphene | −0.92 |
6090 | xamoterol | −0.917 |
6089 | streptozocin | −0.912 |
6088 | tocainide | −0.909 |
D. CMAP analysis with biomarkers that are nominally predictive in females (9 increased and 21 decreased were present in HG-U133A array used by Connectivity Map) | ||
|---|---|---|
rank | cmap name | Score |
6100 | flecainide | −1 |
6099 | Prestwick-682 | −0.997 |
6098 | spiramycin | −0.98 |
6097 | domperidone | −0.974 |
6096 | homatropine | −0.967 |
6094 | isoniazid | −0.964 |
6095 | proguanil | −0.964 |
6093 | phentolamine | −0.958 |
6092 | sulfamonomethoxine | −0.952 |
6091 | fludrocortisone | −0.951 |
6090 | dizocilpine | −0.946 |
6087 | adiphenine | −0.942 |
6088 | tolnaftate | −0.942 |
