Table 2 Estimates of the linear slope of each cognitive test. Illustrations of each trajectory are shown in Fig. 2
From: Polygenic predictors of age-related decline in cognitive ability
Domain | Cognitive test (max. score) | Mean (SD) at age-70 baseline | Mean raw change per year | SE of raw change | p-value | Mean no. of SDs change per year |
|---|---|---|---|---|---|---|
Visuospatial ability | Matrix reasoning | 13.49 (5.13) | –0.133 | 0.016 | 6.12 × 10−16 | –0.033 |
Block design | 33.79 (10.32) | –0.423 | 0.029 | 1.30 × 10−49 | –0.046 | |
Spatial span | 7.36 (1.42) | –0.038 | 0.005 | 1.27 × 10−15 | –0.036 | |
Verbal memory | Logical memory | 71.46 (17.96) | –0.150 | 0.072 | .038 | –0.010 |
Verbal paired associates | 26.44 (9.13) | –0.156 | 0.033 | 3.00 × 10−06 | –0.019 | |
Digit span backwards | 7.73 (2.26) | –0.038 | 0.007 | 1.72 × 10−07 | –0.021 | |
Crystallized ability | NART | 34.48 (8.15) | 0.012 | 0.013 | 0.379 | 0.001 |
WTAR | 41.02 (7.17) | –0.034 | 0.012 | 0.003 | –0.005 | |
Verbal fluency | 42.42 (12.54) | –0.032 | 0.035 | 0.358 | –0.003 | |
Processing speed | Digit-symbol substitution | 56.60 (12.93) | –0.833 | 0.038 | 5.44 × 10−105 | –0.070 |
Symbol search | 24.71 (6.39) | –0.258 | 0.023 | 1.50 × 10−28 | –0.050 | |
Inspection time | 112.14 (11.00) | –0.595 | 0.049 | 2.26 × 10−34 | –0.071 | |
Choice reaction time (ms) | 64.21 (0.09) | –0.008 | 3.57 × 10−04 | 1.86 × 10−108 | –0.104 |
