Table 3 Associations of each polygenic profile score, and APOE e4 status, with general cognitive level (age 70) and slope (age 70–79) in individual-predictor models

From: Polygenic predictors of age-related decline in cognitive ability

Genetic variable

Association with baseline g

Association with g slope

Std. β

SE

p-value

Std. β

SE

p-value

APOE e4

–0.153

0.068

0.025

–0.319

0.068

3.44 × 10−06

Education

0.302

0.032

1.31 × 10−20

0.006

0.044

0.888

Neuroticism

–0.077

0.039

0.047

–0.004

0.048

0.929

Conscientiousness

–0.017

0.035

0.634

0.015

0.044

0.726

Alzheimer’s disease

–0.017

0.035

0.634

–0.073

0.044

0.094

Schizophrenia

–0.148

0.038

1.07 × 10-04

–0.110

0.048

0.022

Major depressive disorder

–0.037

0.035

0.290

–0.008

0.044

0.856

Coronary artery disease

–0.108

0.035

0.002

–0.011

0.044

0.808

Stroke

–0.056

0.035

0.109

–0.016

0.043

0.719

Type 2 diabetes

–0.089

0.035

0.012

–0.010

0.045

0.826

Smoking

–0.178

0.035

3.66 × 10-07

–0.035

0.045

0.438

Height

0.093

0.035

0.008

0.009

0.045

0.833

BMI

–0.135

0.036

1.76 × 10-07

0.028

0.045

0.540

FEV1

0.074

0.037

0.048

0.051

0.047

0.277

Grip strength

–0.041

0.036

0.255

0.035

0.044

0.425

  1. All estimates come from hierarchical latent growth curve structural equation models. Associations are corrected for age at cognitive testing, sex, and four multidimensional scaling components. Bold values are those that were statistically significant after false discovery rate correction for multiple testing. Note that the results for APOE e4 were estimated using extracted factor scores in linear regression models; all other effect sizes were estimated within the structural equation models themselves
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