Fig. 1 | Molecular Psychiatry

Fig. 1

From: MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Fig. 1

Microglia activation is higher in the ACC of Gclm-KO mice than in the ACC of WT mice throughout development. a Confocal images (Scale bar: 30 μm) showing Iba1, CD11b, and CD68 staining in the ACC of Gclm-KO and WT mice at PND20, PND40, and PND90. Graphs represent the quantification of Iba1+ (b), 8-oxoDG intensity (c), CD11b+ (d) and CD68+ (e) cells at PND20, PND40, and PND90. b–e Data are expressed as the mean ± s.e.d. (n = 5–6). Analyzed by 2-way ANOVA with 2 factors (genotype and age) followed by Tukey post hoc test. For genotype effect: ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05; For age effect: &&& P < 0.001

Back to article page