Fig. 3 | Molecular Psychiatry

Fig. 3

From: MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Fig. 3

Inhibition of MMP9 by SB-3CT prevents OxS, microglia activation and the PNN decrease in the ACC of Gclm-KO at PND40, but also the long-term effect at PND90, when applied after an additional oxidative challenge. a Confocal images showing Iba1 (Scale bar: 30 μm), CD68 (Scale bar: 30 μm), 8-oxoDG (Scale bar: 50 μm) and parvalbumin (PV) staining enwrapped with the Wisteria floribunda lectin (WFA) (Scale bar: 50 μm) staining in Gclm-KO and WT mice after 4 injections of SB-3CT (25 mg/kg), each injection separated by 4 days, from PND18 until PND30 as shown in the schematic representation of the protocol and the corresponding quantification graph. b Confocal images showing Iba1 (Scale bar: 30 μm), CD68 (Scale bar: 30 μm), 8-oxoDG (Scale bar: 50 μm) and parvalbumin (PV) staining enwrapped with the Wisteria floribunda lectin (WFA) (Scale bar: 50 μm) and the corresponding quantification graph at PND90 after GBR (5 mg/kg) injection on PND10-20 followed by 4 injections of SB-3CT (25 mg/kg), each injection separated by 4 days, from PND21 until PND33, as shown in the schematic representation of the protocol. a, b Data are expressed as the mean ± s.e.d. (n = 5–6). ** P < 0.01; ***P < 0.001; analyzed by 2-way ANOVA followed by Tukey post hoc test. I.P.inj., intraperitoneal injection; s.c. inj., subcutaneous injection

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