Fig. 2 | Molecular Psychiatry

Fig. 2

From: Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval

Fig. 2

µRGABA but not µRGlut or µRAstro deletion prevents the EP stress-induced impairment of spatial memory retrieval. a-d The effects of stress on memory retrieval of µR−/− (a), µRGABA−/− (b), µRGlut−/− (c), and µRAstro−/− mice (d). *, target vs. opposite within-group, paired Student’s t-test. The target time ratio F3,29 = 10.95, p = 0.000 for µR−/−; F3,36 = 3.76, p = 0.019 for µRGABA−/− mice; F3,38 = 11.86, p = 0.000 for µRGlut−/−; and F3,39 = 3.44, p = 0.026 for µRAstro−/−; one-way ANOVA. #, vs. the stressed µR+/+, µRGABA+/+, µRGlut+/+, or µRGlut+/+, respectively. One symbol, p < 0.05; two symbols, p < 0.01; three symbols, p < 0.001. US unstressed, S stressed

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