Fig. 1 | Molecular Psychiatry

Fig. 1

From: Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1)

Fig. 1

Differentially methylated CpGs in the prefrontal cortex (BA10) of alcohol use disorder (AUD) subjects. a Hierarchical clustering of 23 control (green) and 23 AUD (yellow) subjects using a colored heatmap based on methylation levels (blue to red: low-to-high methylation levels) of 5254 CpGs. b Location of CpG sites relative to promoters, 5′UTRs, exons, gene bodies, and intergenic regions. Hypomethylated CpGs are shown in white, hypermethylated in black. c Volcano plot of effect size [log2(fold change)] vs. log10(p-value) of 787,426 CpGs. Red dots represent 1218 CpGs with pnominal ≤ 0.001. d IPA® hierarchical interaction network. The lines between genes represent known interactions (solid—direct; dashed—indirect). Genes are referred to as nodes and the intensity of the node color indicates the degree of hyper- (red) or hypo- (green) methylation of a given gene

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