Table 2 Marginal effects of hair cortisol and C-reactive protein on persistent depressive symptoms: overall, cognitive-affective, and somatic factors

	Overall factor					Cognitive-affective factor					Somatic factor
	B	SE	p-value	95% CI	β	B	SE	p-value	95% CI	β	B	SE	p-value	95% CI	β
Hair cortisol (N = 4761)
Model 1 (unadjusted)	0.077	0.024	0.001	0.030; 0.124	0.062	0.054	0.027	0.045	0.001; 0.107	0.075	0.104	0.026	<0.001	0.052; 0.155	0.127
Model 2 (partially adjusted)	0.084	0.022	<0.001	0.040; 0.128	0.068	0.060	0.027	0.026	0.007; 0.112	0.068	0.112	0.026	<0.001	0.062; 0.163	0.115
Model 3 (fully adjusted)	0.054	0.021	0.011	0.012; 0.096	0.043	0.032	0.027	0.223	−0.020; 0.084	0.034	0.075	0.024	0.002	0.027; 0.122	0.071
C-reactive protein (N = 5784)
Model 1 (unadjusted)	0.214	0.022	<0.001	0.171; 0.256	0.170	0.166	0.025	<0.001	0.117; 0.214	0.220	0.273	0.024	<0.001	0.226; 0.320	0.325
Model 2 (partially adjusted)	0.145	0.021	<0.001	0.104; 0.186	0.116	0.097	0.024	<0.001	0.049; 0.145	0.112	0.201	0.023	<0.001	0.155; 0.246	0.209
Model 3 (fully adjusted)	0.104	0.020	<0.001	0.065; 0.143	0.082	0.059	0.024	0.015	0.012; 0.106	0.062	0.151	0.023	<0.001	0.107;0.195	0.145
Difference between somatic and cognitive-affective scores
	Hair cortisol				C-reactive protein
	Difference	SE	p-value	95% CI	Difference	SE	p-value	95% CI
Model 1 (unadjusted)	−0.050	0.037	0.182	−0.123; 0.023	−0.107	0.035	0.002	−0.175; −0.038
Model 2 (partially adjusted)	−0.052	0.037	0.165	−0.125; 0.021	−0.104	0.033	0.002	−0.169; −0.038
Model 3 (fully adjusted)	−0.043	0.036	0.234	−0.113; 0.027	−0.092	0.033	0.005	−0.157; −0.026

Data source: ELSA, waves 1–8 B: regression coefficient. β: standardised regression coefficient. Estimator: WLSMV. Model 1 = unadjusted. Model 2: adjusted for demographic, socioeconomic, lifestyle, and hair (cortisol only) characteristics. Model 3:Model 2+ chronic disease and medication use
SE standard error, CI confidence interval

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