Table 1 ICD10 codes for mothers of NOWS babies at Geisinger (526 infants born to 473 mothers, 11/2007–4/2019)

ICD10	ICD10 Description	Count 3 calls	%3 calls
O09.899	Supervision of other high risk pregnancies, unspecified trimester	332	70.19
O99.320	Drug use complicating pregnancy, unspecified trimester	279	58.99
F11.20	Opioid dependence, uncomplicated	273	57.72
Z72.0	Tobacco use	159	33.62
F32.9	Major depressive disorder, single episode, unspecified	152	32.14
F19.20	Other psychoactive substance dependence, uncomplicated	151	31.92
B18.2	Chronic viral hepatitis C	149	31.50
Z34.80	Encounter for supervision of other normal pregnancy, unspecified trimester	141	29.81
Z23	Encounter for immunization	138	29.18
O09.893	Supervision of other high risk pregnancies, third trimester	138	29.18
F17.200	Nicotine dependence, unspecified, uncomplicated	136	28.75
O99.330	Smoking (tobacco) complicating pregnancy, unspecified trimester	132	27.91
Z79.891	Long term (current) use of opiate analgesic	126	26.64
O09.892	Supervision of other high risk pregnancies, second trimester	113	23.89
F19.10	Other psychoactive substance abuse, uncomplicated	109	23.04

Year	2007	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	2019	Total
Number of Infants born with NOWS	1	7	16	29	29	33	52	61	60	72	63	73	30	526

The most common ICD-10 codes and description of the codes are listed for women who gave birth to infants with NOWS at Geisinger during the interval, 11/2007–4/2019. These are only those NOWS children and mothers who have been seen at Geisinger in the past 2 years, so they are active patients. The ICD-10 code count (from a total of 473 mothers) with each ICD-10 code and the percent (from a total of 473) is given. The term, three calls, indicates that three instances of an ICD-10 code was sufficient for that code to be included. In the bottom panel, the year of birth for the NOWS infants is listed. Note the trend for greater numbers of NOWS infants born at Geisinger in the last decade

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