Table 1 Descriptive characteristics of study population separately for individuals with tic-related obsessive-compulsive disorder (OCD), non-tic-related OCD, and individuals unaffected by OCD
From: A population-based family clustering study of tic-related obsessive-compulsive disorder
Individuals with tic-related obsessive-compulsive disorder n = 1257 | Individuals with non-tic-related obsessive-compulsive disorder n = 20,975 | Individuals unaffected by obsessive-compulsive disorder n = 4,063,135 | |
|---|---|---|---|
Males, n (%) | 892 (70.96) | 8588 (40.94) | 2,089,286 (51.42) |
Age at first OCD diagnosis, median (IQR) | 15.70 (12.17–21.46) | 23.13 (17.81–30.03) | – |
Age of mother at birth of offspring, median (IQR) | 28.75 (25.08–32.33) | 28.25 (24.58–32.25) | 28.17 (24.59–32.00) |
Age of father at birth of offspring, median (IQR) | 31.08 (27.58–35.50) | 30.75 (27.00–35.25) | 30.66 (27.00–34.84) |
Psychiatric comorbidities, mean (SD) | 1.94 (1.32) | 1.56 (1.24) | 0.16 (0.53) |
ASD, n (%) | 459 (36.52) | 2777 (13.24) | 39,875 (0.98) |
ADHD, n (%) | 686 (54.57) | 3558 (16.96) | 105,968 (2.61) |
Schizophrenia, n (%) | 106 (8.43) | 1673 (7.98) | 20,184 (0.50) |
Bipolar disorder, n (%) | 80 (6.36) | 1731 (8.25) | 23,250 (0.57) |
Depression, n (%) | 394 (31.34) | 9295 (44.31) | 162,402 (4.00) |
Anxiety disorders, n (%) | 534 (42.48) | 11,938 (56.92) | 210,226 (5.17) |
Intellectual disability, n (%) | 104 (8.27) | 807 (3.85) | 30,000 (0.74) |
Epilepsy, n (%) | 53 (4.22) | 593 (2.83) | 48,890 (1.20) |
Organic brain disorder, n (%) | 19 (1.51) | 289 (1.38) | 6935 (0.17) |
Sub-cohorts of relatives | |||
Twins, n (%) | 32 (2.55) | 375 (1.79) | 74,717 (1.84) |
Full siblings, n (%) | 913 (72.63) | 15,608 (74.41) | 3,056,839 (75.23) |
Maternal half siblings, n (%) | 257 (20.45) | 3783 (18.04) | 560,953 (13.81) |
Paternal half siblings, n (%) | 273 (21.72) | 3897 (18.58) | 608,861 (14.99) |
Cousins, n (%) | 874 (69.53) | 14,455 (68.92) | 2,693,527 (66.29) |
