Fig. 1

Regional heterogeneity of microglia in the brain. Microglia differ in their cell number, cellular and subcellular structures, molecular signature as well as relevant functions in different mouse brain areas. Microgliome genes were selected based on several seminal transcriptomic studies [25, 26, 63, 68, 107, 115, 140] and their RNAseq data in 13 mouse brain regions were retrieved from the human protein atlas. An expression heatmap was drawn in Morpheus (Broad Institute). Brain regions were clustered according to K-means of expression levels (grouping score at 5, Pearson’s method). The data are also provided in Supplementary Table 1