Fig. 5 | Molecular Psychiatry

Fig. 5

From: MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Fig. 5

miR-298 inhibitor reverses miR-298-mediated reduction of BACE1 protein in human primary brain culture. a Primary human mixed-brain cell cultures were mock-transfected or transfected with APP siRNA, miR-298, miR-298 inhibitor, miR-298 plus inhibitor, or NCM. Cells were cultured further after transfection, lysed, and lysate run on SDS–PAGE followed by western blotting for BACE1. b Western blot of BACE1 levels. c The Addition of miR-298 inhibitor reverses effect of miR-298 on BACE1 levels. n = 4, pairwise differences (p ≤ 0.05) are indicated by letters. Treatments sharing a letter did not significantly differ.

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