Fig. 7 | Molecular Psychiatry

Fig. 7

From: MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Fig. 7

miR-298 results in reduction of Aβ40, Aβ42 in human mixed-brain culture. Cultures were treated with miRNA mimics or inhibitors and levels of (a) Aβ40 peptide (pairwise differences, p ≤ 0.05, are indicated by letters. Treatments sharing a letter did not significantly differ.) and of (b) Aβ42 peptide in conditioned media measured. No pairwise differences were significant for Aβ42, indicated by "ns". Red point indicates a statistical outlier, dashed line for "NCM" indicates mean excluding outlier. Significance for model and pairwise significances were not altered by excluding outlier from analysis. A-B: n = 4, p < 0.05.

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