Fig. 9 | Molecular Psychiatry

Fig. 9

From: MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

Fig. 9

Human miR-298, but not mouse miR-298, reduces APP and BACE1 expression in human glioblastoma cells. a Homology between mature hsa-miR-298 and mmu-miR-298. b Western blot of miR-298 reduction of APP and BACE1. β-actin served as a loading control. Densitometry of c APP and d BACE1 normalized to β-actin. n = 4, Pairwise differences (p ≤ 0.05) are indicated by letters. Treatments sharing a letter did not significantly differ. Human miR-186 was included as a human miRNA not expected to alter APP levels (β-actin-adjusted) in U373 cells.

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