Table 1 Striatum-to-whole-brain functional connectivity results.

From: Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals

Effect

Seed

Label

Size (voxels)

Peak x

Peak y

Peak z

F-statistic

Alpha

Group × treatment

VS

Right putamen

79

21

5.2

−3.8

F(1,36) = 27.06

<0.01

 

Left dlPFC

51

−28

43.8

31.2

F(1,36) = 20.54

<0.04

DC

Right vlPFC

52

52.5

36.8

3.2

F(1,32) = 20.37

<0.03

DCP

pgACC

58

7

33.2

−0.2

F(1,36) = 17.18

<0.03

VRP

Left OFC

81

−21

26.2

−10.8

F(1,32) = 28.22

<0.01

 

Right OFC

66

28

26.2

3.2

F(1,32) = 16.96

<0.02

  1. All clusters were corrected for multiple comparisons with a cluster-forming threshold of p < 0.005 (uncorrected) and family–wise error (FWE) cluster correction at p <  0.05 using Monte-Carlo simulation in AFNI.
  2. VS ventral striatum, DC dorsal caudate, DCP dorsal caudal putamen, VRP ventral rostral putamen, dlPFC dorsolateral prefrontal cortex, vlPFC ventrolateral prefrontal cortex, pgACC perigenual anterior cingulate cortex, OFC orbitofrontal cortex.