Fig. 2: Details of the genome-wide top hit rs6035856. | Molecular Psychiatry

Fig. 2: Details of the genome-wide top hit rs6035856.

From: Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Fig. 2

a Local association and b forest plot of the genome-wide top variant (rs6035856). The forest plot shows the odds ratio (OR) and 95% confidence intervals (CI) on the x-axis, by dataset and for the pooled analysis. Detailed OR statistics can be found in Table S2b. Note to forest plot: the sibling-based dataset ENall1 was analyzed genome-wide through linear mixed modelling (in FastLMM) for computational reasons, while its OR, as shown here, was computed via a Wald test in a logistic mixed model (GMMAT), to make it comparable to the other ORs produced through logistic regression (PLINK). Hence, the result of the pooled analysis—which here was performed through the inverse variance-based method—is slightly discrepant from the original genome-wide analysis (see Table 2).

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