Table 1 General descriptive statistics and recruitment criteria of the datasets analyzed in the study.

From: Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Dataset

Recruitment

Language

Age range, years (mean, SD)b

IQ inclusion criteria

N after QC (cases:controls)

AGSa

Unrelated cases and controls

German

8–19 (10.7, 2.4)

Age-appropriate WISC Block Design score [99, 100] ≥7 Age-appropriate WISC Similarities score [99, 100] ≥6

1454 (1047:407)

Finland

 

Finnish

  

324 (161:163)

France

 

French

  

163 (106:57)

Hungary

 

Hungarian

  

241 (90:151)

Netherlands

 

Dutch

  

284 (136:148)

ENall1b

Related cases from Colorado + related cases from UK (Oxford) + unrelated unscreened controls from UK general population (WTCC2_1958)

English

8–19 (11.5, 2.7)

Colorado: average score of age-adjusted WISC-R/WAIS-R verbal IQ and performance IQ, multiple subtests) [101] ≥80 [28] UK: average of age-adjusted standardized BAS/WAIS-R similarities subtest and BAS matrices subtest score [102, 103] ≥80 [28]

3313 (554:2759)

ENall2b

Unrelated cases from UK (Cardiff) + unrelated unscreened controls from UK general population (WTCC2_NBS)

English

5–31 (11.8, 3.6)

Average of age-adjusted standardized BAS/WAIS-R similarities subtest and BAS matrices subtest score [102, 103] ≥80 [28]

2767 (180:2587)

  1. IQ intelligence quotient, DD developmental dyslexia, WISC Wechsler Intelligence Scale for Children, WAIS Wechsler Adult Intelligence Scale—Revised, BAS British Ability Scale.
  2. aAustria–Germany–Switzerland.
  3. bIn the English-speaking datasets (i.e., ENall1 and ENall2) age and IQ information refers only to cases, since no such data were available from the general population control cohorts.
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