Table 2 Most significant single-variant associations (p < 5 × 10−7) detected in the present GWAS.

From: Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

SNP

REF allele

ALT allele

REF allele frequencya,b

Z-scoreb

p

Directionb

I2 (p)c

Position (chr:bp)

Position within gene

Gene symbol

Distance from gene (bp)

rs6035856

G

T

0.55

5.329

9.88 × 10−8

+++++++

0 (0.91)

20:2188542

intron

LOC388780

–

rs6035857

A

C

0.55

5.329

9.88 × 10−8

+++++++

0 (0.91)

20:2188544

intron

LOC388780

–

rs6082416

G

C

0.55

5.153

2.56 × 10−7

+++++++

0 (0.85)

20:2195832

downstream

LOC388780

2035

rs6137325

G

T

0.59

5.147

2.65 × 10−7

+++++++

0 (0.91)

20:2187943

exon

LOC388780

–

rs2094530

C

T

0.22

5.098

3.43 × 10−7

?--???-

0 (0.82)

13:51564457

downstream

GUCY1B2

4190

rs6047381

C

T

0.58

5.089

3.59 × 10−7

+++++++

0 (0.84)

20:2185357

upstream

LOC388780

2217

rs6137326

C

T

0.59

5.083

3.72 × 10−7

+++++++

0 (0.91)

20:2187944

exon

LOC388780

–

rs6132418

A

T

0.58

5.08

3.78 × 10−7

+++++++

0 (0.85)

20:2186281

upstream

LOC388780

1293

  1. aAverage allele frequency computed for reference (REF) alleles over all the datasets analyzed.
  2. bAllele frequencies, meta-analysis Z-scores, and directions of effect refer to REF alleles. Directions of effect are reported for each single dataset analyzed, in the following order: AGS, Finland, France, Holland, Hungary, ENall1, ENall2. “+” means that the major allele is the risk allele, while “?” indicates that the variant was not tested in the corresponding dataset.
  3. cI2 test for heterogeneity of genetic effect across datasets (the closer to “0”, the more homogenous is the genetic effect).
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