Table 3 Results of the polygenic score (PGS) analysis for the different training traits/disorders tested.

From: Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Trait/disorder PGS

OR [95% CI]

R2 (%)

p

Training GWAS (Reference)

Training GWAS N (cases/controls)

ADHD

1.23 [1.16; 1.3]

0.73

7.66 × 10−13

[67]

53,293 (19,099/34,194)

ASD

1.01 [0.96; 1.07]

<0.01

0.69

[68]

46,351 (18,382/27,969)

BD

1.53 [1.44; 1.63]

2.80

1.33 × 10−43

[66]

51,710 (20,352/31,358)

MDD

1.01 [0.95; 1.06]

<0.01

0.83

[70]

500,199 (170,756/329,443)

SCZ

1.36 [1.28; 1.45]

1.35

3.65 × 10−22

[69]

77,096 (33,640/43,456)

Cross-Disorder

1.23 [1.16; 1.30]

0.69

3.12 × 10−12

[61]

438,997 (162,151/276,846)

EduYears

0.86 [0.82; 0.91]

0.39

1.95 × 10−7

[63]

766,345

Intelligence

0.72 [0.68; 0.76]

1.79

9.40 × 10−29

[62]

269,867

  1. We report odds ratios (OR) for dyslexia with 95% confidence intervals (95% CI) per standardized PGS in our dataset, along with relevant R2 and p values, at pT = 0.05 in the training GWAS. Full results for the different pT thresholds tested are reported in Table S4a–h. Statistically significant associations (p < 4.5 × 10−4) are highlighted in bold.
  2. ADHD attention deficit hyperactivity disorder, ASD autism spectrum disorder, MDD major depressive disorder, BD bipolar disorder, SCZ schizophrenia, CROSS-DISORDER shared genetic basis of ADHD, ASD, BD, MDD, SCZ, anorexia nervosa, obsessive-compulsive disorder and Tourette syndrome based on the GWAS meta-analysis by the Cross-Disorder Group of the Psychiatric Genomics Consortium [61], EduYears years of education completed.
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