Fig. 2: Loss of serotonergic STAT3 leads to differential behavioural reactivity in stressful behavioural paradigms. | Molecular Psychiatry

Fig. 2: Loss of serotonergic STAT3 leads to differential behavioural reactivity in stressful behavioural paradigms.

From: STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology

Fig. 2

Motor function was not impacted by knockout of STAT3 in serotonergic cells, as (A) locomotor activity in the OFT and (B) motor coordination in the RR were similar between groups. C No differences between genotypes in sucrose preference were found in the SPT. D Average latency to feed in an adverse environment was reduced in KO animals relative to controls in the NSF. No effect of serotonergic STAT3 knockout on (E) body mass, (F) body mass lost during the food restriction period preceding the NSF, or (G) food consumption immediately after the NSF test. H KO animals showed markedly reduced passive immobility behaviour in the FST in comparison to controls. Avoidance of the adverse compartments in (I) LDB and (J) EPM were unchanged by serotonergic STAT3 knockout. EPM: elevated plus maze; FST: forced swim test; KO: knockout; LDB: light-dark box; NSF: novelty-suppressed feeding; OFT: open field test; RR: Rotarod; SPT: sucrose preference test; STAT3: signal transducer and activator of transcription 3. All data are presented as mean ± SD. *p < 0.05; ***p < 0.001.

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