Fig. 3: miRNA expression in primary neuronal cultures and in AD brains. | Molecular Psychiatry

Fig. 3: miRNA expression in primary neuronal cultures and in AD brains.

From: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Fig. 3

a Hybridization experiments in rat postnatal hippocampal neuronal cultures enabling single-copy detection of miRNA combined with immunocytochemistry against astrocytic (SOX9) and neuronal (NeuN) markers. Scale bar = 20 µm. The box plot shows the quantification of miRNA copy number in SOX9- or NeuN-positive cells (N > 30 cells for each condition). Black rectangles and red plus signs indicate sample mean and outliers, respectively. b Relative miRNA expression levels in temporal lobes of nondemented (CTL) and AD groups. Mann–Whitney test; ****p < 0.0001.

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