Fig. 7: FERMT2 underexpression alters PPF and LTP in an APP-dependent manner. | Molecular Psychiatry

Fig. 7: FERMT2 underexpression alters PPF and LTP in an APP-dependent manner.

From: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Fig. 7

a Paired-pulse facilitation (PPF) as a function of the interstimulus interval 7 days after viral injection of indicated lentivirus. n = 3 mice, 2 slices per animal. b Exemplary fEPSP traces during baseline (light line) and 30–60 min after LTP induction (dark line). c Time course of the average slope of elicited fEPSP responses following LTP induction by a tetanic stimulation protocol in hippocampal CA1 synapses after viral injection. Time point 0 represents the delivery of the tetanic stimulation. Slopes of each fEPSP are normalized by the baseline and plotted against time. d Box plots of the average slope response during 30–60 min post LTP induction. HFS high-frequency stimulation. n = 5 mice, two slices per animal. e Normalized average slope of fEPSP evoked in hippocampal slices from animals injected with the indicated lentivirus. Recordings have been performed in the stratum radiatum of hippocampal CA1 region with electrical stimulation of Schaffer collaterals (see “Methods”). Unpaired t test; *p < 0.05; **p < 0.01.

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