Fig. 1: A diagram showing the general workflow used for our study. | Molecular Psychiatry

Fig. 1: A diagram showing the general workflow used for our study.

From: Autophagy, apoptosis, and neurodevelopmental genes might underlie selective brain region vulnerability in attention-deficit/hyperactivity disorder

Fig. 1

We collected regional postmortem brain transcriptome profiles from Allen Brain Atlas and summary statistics from two neuroimaging meta-analyses by the ENIGMA Consortium for ADHD. We analyzed the postmortem brain data for correlations between gene-set expression levels of apoptosis, autophagy, neurodevelopment, neurotransmitter, oxidative stress, and ADHD candidate genes with brain size differences in ADHD cases from the ENIGMA studies. We also deconvoluted the regional postmortem brain transcriptome profiles into discrete cell types and tested for a correlate between cell abundance and volumetric reductions in ADHD. We tested for enrichment of GWAS signals associated with ADHD among gene sets of interest (i.e., cell-type marker genes, Gene Ontology gene sets). GEO Gene Expression Omnibus, GWAS genome-wide association study, scRNA-seq single-cell RNA-sequencing.

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