Table 3 Top-sites associated with aggressive behavior from the combined EWAMA of cord blood and peripheral blood (FDR 5%).

From: DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

CpG ID

CHR

Positiona

Gene

Gene Expression Associated With CpGs

N M1

Z score M1

P value M1

Z score M2

P value M2

cg05575921

5

373378

AHRR

EXOC3

15,666

−8.995

2.36E-19

−4.159

3.20E-05

cg21161138

5

399360

AHRR

EXOC3

15,661

−7.573

3.66E-14

−3.155

1.61E-03

cg26703534

5

377358

AHRR

EXOC3

15,665

−6.695

2.16E-11

−2.058

3.96E-02

cg14753356

6

30720108

 

FLOT1

15,666

−6.672

2.52E-11

−3.342

8.33E-04

cg22132788

7

45002486

MYO1G

 

10,847

6.313

2.74E-10

3.637

2.76E-04

cg06126421

6

30720080

 

FLOT1, TUBB, LINC00243

10,864

−6.196

5.78E-10

−2.154

3.13E-02

cg07826859

7

45020086

MYO1G

 

10,863

−6.017

1.77E-09

−3.665

2.48E-04

cg09935388

1

92947588

GFI1

 

15,661

−5.906

3.51E-09

−3.222

1.27E-03

cg25648203

5

395444

AHRR

EXOC3

15,657

−5.583

2.37E-08

−2.233

2.55E-02

cg12062133

8

142548839

  

14,482

5.462

4.71E-08

4.881

1.06E-06

cg05951221

2

233284402

  

10,864

−5.443

5.25E-08

−1.679

9.32E-02

cg14817490

5

392920

AHRR

EXOC3

10,863

−5.407

6.43E-08

−2.152

3.14E-02

cg14179389

1

92947961

GFI11

 

15,666

−5.35

8.80E-08

−3.888

1.01E-04

cg05432213

15

35086985

ACTC1

 

15,666

5.144

2.68E-07

4.87

1.12E-06

cg03636183

19

17000585

F2RL3

F2RL3

15,666

−5.124

3.00E-07

−0.909

3.63E-01

cg09022230

7

5457225

TNRC18

 

15,666

−5.071

3.95E-07

−3.024

2.49E-03

cg12803068

7

45002919

MYO1G

RP4-647J21.1

15,666

4.93

8.22E-07

2.493

1.27E-02

cg23916896

5

368804

AHRR

 

15,652

−4.915

8.86E-07

−2.332

1.97E-02

cg04180046

7

45002736

MYO1G

RP4-647J21.1

15,665

4.884

1.04E-06

2.989

2.80E-03

cg02228160

5

143192067

HMHB1

 

10,852

4.867

1.13E-06

3.451

5.58E-04

cg03519879

14

74227499

C14orf43

 

15,663

−4.859

1.18E-06

−3.609

3.08E-04

cg00310412

15

74724918

SEMA7A

SEMA7A

15,666

−4.854

1.21E-06

−2.608

9.11E-03

cg13165240

17

3715743

C17orf85

 

15,664

4.838

1.31E-06

4.436

9.16E-06

cg02895948

1

208204062

PLXNA2

PLXNA2

10,865

−4.811

1.51E-06

−4.448

8.68E-06

cg12147622

10

74021432

  

15,662

−4.796

1.62E-06

−3.312

9.26E-04

cg26883434

5

111091560

C5orf13

 

14,540

4.773

1.81E-06

4.739

2.15E-06

cg03991871

5

368447

AHRR

EXOC3

10,857

−4.753

2.01E-06

−2.374

1.76E-02

cg06946797

16

11422409

  

15,666

−4.75

2.03E-06

−3.317

9.08E-04

cg00891184

1

10272185

KIF1B

 

15,662

4.746

2.07E-06

4.421

9.82E-06

cg09243533

1

19281949

IFFO2

 

15,666

−4.74

2.14E-06

−4.003

6.26E-05

cg03935116

12

31476565

FAM60A

FAM60A

15,665

−4.735

2.19E-06

−3.664

2.48E-04

cg11554391

5

321320

AHRR

 

15,666

−4.717

2.39E-06

−2.731

6.32E-03

cg19825437

3

169383292

  

15,664

−4.663

3.12E-06

−3.094

1.98E-03

cg00624037

12

89315201

  

15,663

4.633

3.61E-06

4.081

4.49E-05

cg01940273

2

233284934

  

15,666

−4.621

3.82E-06

−0.305

7.61E-01

cg25949550

7

145814306

CNTNAP2

 

15,666

−4.615

3.94E-06

−2.333

1.96E-02

cg23067299

5

323907

AHRR

 

10,865

4.615

3.94E-06

3.21

1.33E-03

cg04387347

16

88537187

ZFPM1

 

9563

4.603

4.17E-06

2.678

7.42E-03

cg02325250

5

131409289

CSF2

 

15,664

−4.597

4.28E-06

−3.635

2.78E-04

cg14560430

3

32863175

TRIM71

 

15,665

−4.569

4.90E-06

−3.924

8.70E-05

cg03844894

15

35086967

ACTC1

 

15,666

4.567

4.94E-06

4.176

2.97E-05

cg21611682

11

68138269

LRP5

 

14,859

−4.561

5.08E-06

−1.721

8.53E-02

cg20673321

19

48049233

ZNF541

 

15,666

4.538

5.67E-06

4.672

2.98E-06

  1. aGenome build 37. M1 = Model 1: correction for sex, age at blood sampling, white blood cell percentages (measured or imputed), and technical covariates. M2 = Model 2 included the same predictors plus body-mass-index (BMI) and smoking status in adolescents and adults (current smoker, former smoker or never smoked). Note that no CpGs were epigenome-wide significant or FDR-significant in the adjusted meta-analyses (model 2).