Table 1 Bipolar disorder sequencing cohorts.

Study	Ethnicity	Total N	Case/Control N	Female (%)	B1D/B2D/SAB/NOS/UNK (%)	P-LP SNVs	Exonic SNVs	Exonic coverage: median (25–75%)
BRIDGES^a	US-Caucasian	3,556	1712/1844	32.4	100/0/0	4,812	680,910	8 (6–11)
RareBLISS	US-Caucasian	2,000	961/1039	53.0	90.8/0/9.2	3,394	465,504	78 (42–101)
Sweden	Swedish-Caucasian	2,787	831/1956	53.8	65.8/30.3/0.4/1.7/1.8	1,945	328,066	28 (24–37)
KPNC-EUR	US-Caucasian	384	192/192	71.6	100/0/0	511	108,307	34 (22–51)
KPNC-AFR	US-African American	191	96/95	71.2	100/0/0	308	132,872	39 (25–57)
KPNC-LAT	US-Latino	198	98/100	72.7	100/0/0	298	101,368	40 (26–60)
KPNC-EAS	US-East Asian	193	97/96	63.7	100/0/0	334	88,884	39 (26–58)
All		9,309	3987/5322	47.1	90.6/6.3/2.3 0.4/0.4	9,883	1,328,324

We examined protein-coding (exome) sequence data in 9309 individuals of predominantly European ancestry from four independent studies. Cases and controls were recruited at ~1:1 ratio except in the Sweden cohort (~1:2 cases to controls). The Kaiser Permanente Northern California (KPNC) cohort was comprised of four race/ethnicity groups: 40% non-Hispanic white, 20% African American, 20% Latino, and 20% East Asian. The number of unique exon variants (including exonic, splicing, and 3’ and 5’ UTR regions) is listed for each cohort and across studies.
SNV single nucleotide variant, WES whole-exome sequencing, BRIDGES Bipolar Research in Deep Genome and Epigenome Sequencing Study, RareBLISS Rare Bipolar Loci Identification through Synaptome Sequencing, EUR European ancestry, AFR African American ancestry, LAT Latino ancestry, EAS East Asian ancestry, B1D bipolar 1 disorder, B2D bipolar 2 disorder, SAB Schizoaffective disorder, bipolar type, NOS No otherwise specified, Miss missing specific diagnosis.
^aWhole-genome sequencing was performed in BRIDGES. Exome sequencing was performed in all other BSC cohorts.

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