Table 2 Altered pathways in the blood of patients with major depressive disorder.

From: An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder

Pathways

p valuea

Metabolic pathways identified by MetaboAnalyst

  Nitrogen metabolism

<0.001

  Aminoacyl-tRNA biosynthesis

<0.001

  Fatty acid biosynthesis

0.001

  Alanine, aspartate and glutamate metabolism

0.001

  Linoleic acid metabolism

0.008

  Glycine, serine and threonine metabolism

0.009

  Cyanoamino acid metabolism

0.009

  Cysteine and methionine metabolism

0.013

  Taurine and hypotaurine metabolism

0.014

  Arginine and proline metabolism

0.031

Canonical pathways identified by IPA

  tRNA charging

<0.001

  Glycine betaine degradation

<0.001

  l-Serine degradation

<0.001

  Asparagine biosynthesis I

0.003

  Palmitate biosynthesis I (animals)

0.006

  Superpathway of methionine degradation

0.007

  Cysteine biosynthesis III (mammalia)

0.010

  NAD biosynthesis II (from tryptophan)

0.021

  Folate transformations I

0.021

  HIF1α signaling

0.024

  Asparagine degradation I

0.035

  Glutamine degradation I

0.035

  Pyruvate fermentation to lactate

0.047

  Glycine biosynthesis III

0.047

  Alanine degradation III

0.047

  Alanine biosynthesis II

0.047

  Myo-inositol biosynthesis

0.047

  l-Cysteine degradation II

0.047

  Phosphatidylethanolamine biosynthesis III

0.047

  Glycine biosynthesis I

0.047

  1. ap values were calculated from hypergeometric tests in MetaboAnalyst, and from Fisher’s exact tests in Ingenuity pathways analysis
Back to article page