Fig. 2: APOEε4 exerts a gene-dose effect on tau aggregation when interacting with amyloid-β.
From: APOEε4 potentiates the relationship between amyloid-β and tau pathologies
a The interaction between [18F]Florbetapir and a single APOEε4 gene was related to increased [18F]Flortaucipir uptake in the posterior cingulate posterior parietal, lateral temporal temporooccipital, and orbitofrontal cortices. b Homozygous ε4 carriers demonstrated a more widespread relationship between [18F]Florbetapir and [18F]Flortaucipir uptake, with [18F]Flortaucipir uptake in the posterior cingulate, precuneus, posterior parietal, medial prefrontal, and orbitofrontal cortices. Tau-PET uptake in the temporooccipital cortex was observed only for the interaction between [18F]Florbetapir SUVR and one APOEε4 allele. Effects of homozygosity were observed in the tau-PET uptake in the precuneus, anterior cingulate, and medial prefrontal cortices were observed only for the interaction between [18F]Florbetapir SUVR and two APOEε4 alleles. T-statistical parametric maps were corrected for multiple comparisons using a Random Field Theory cluster threshold of P < 0.005, overlaid on the ADNI reference template. Age, clinical diagnosis, and amyloid-β SUVR were employed as covariates in each model. Results remained comparable when using partial volume corrected PET data.
