Fig. 3: Interaction between amyloid-β and APOEε4 is related to increased CSF phosphorylated tau pathology. | Molecular Psychiatry

Fig. 3: Interaction between amyloid-β and APOEε4 is related to increased CSF phosphorylated tau pathology.

From: APOEε4 potentiates the relationship between amyloid-β and tau pathologies

Fig. 3

The synergistic effect between APOEε4 and neocortical [18F]Florbetapir SUVR was related to increased CSF p-tau. While the heterozygotes (β4 = 20.31, se = 6.59, p < 0.0001, represented in green) had a milder slope than the homozygotes (β5 = 33.01, se = 14.24, p = 0.01, represented in blue), this difference in slopes was not statistically significant (p = 0.07). Age, clinical diagnosis, and amyloid-β SUVR were employed as covariates.

Back to article page