Table 2 Main and interactive effects of amyloid-PET and APOEε4 on tau-PET uptake and CSF p-tau.

From: APOEε4 potentiates the relationship between amyloid-β and tau pathologies

(A) TRIAD tau-PET cohort

Brain region

Amyloid-PET main effect β estimate (SE)

APOE4 main effect β estimate (SE)

Total of amyloid-PET main effect β estimate and APOE4 main effect β estimate

Amyloid-PET × APOE4 interaction effect β estimate (SE)

Posterior cingulate

0.19 (0.1)

0.02 (0.09)

0.17

0.26 (0.15)

Precuneus

0.13 (0.11)

−0.03 (0.09)

0.10

0.23 (0.14)

Inferior parietal

0.29 (0.1)

−0.07 (0.09)

0.22

0.23 (0.14)

Medial prefrontal

0.20 (0.08)

−0.04 (0.07)

0.16

0.25 (0.13)

Occipital

0.25 (0.07)

−0.02 (0.07)

0.23

0.41 (0.1)

(B) ADNI tau-PET cohort

Brain region

Amyloid-PET main effect β estimate (SE)

Single APOE4 Main Effect β Estimate (SE)

Total of amyloid-PET main effect β estimate and single APOE4 main effect β estimate

Amyloid-PET × Single APOE4 interaction effect β estimate (SE)

Posterior cingulate

0.16 (0.05)

−0.04 (0.03)

0.12

0.28 (0.1)

Lateral temporal

0.37 (0.06)

−0.03 (0.03)

0.33

0.36 (0.11)

Inferior parietal

0.21 (0.05)

−0.02 (0.04)

0.19

0.29 (0.11)

Orbitofrontal

0.18 (0.05)

−0.04 (0.03)

0.14

0.24 (0.08)

Temporooccipital

0.21 (0.06)

−0.01 (0.04)

0.20

0.44 (0.11)

(C) ADNI tau-PET cohort

Brain region

Amyloid-PET main effect β estimate (SE)

Double APOE4 main effect β estimate (SE)

Total of amyloid-PET main effect β estimate and double APOE4 main effect β estimate

Amyloid-PET × Double APOE4 interaction effect β estimate (SE)

Posterior cingulate

0.21 (0.05)

−0.07 (0.06)

0.14

0.39 (0.13)

Lateral temporal

0.24 (0.05)

−0.001 (0.06)

0.24

0.49 (0.15)

Inferior parietal

0.18 (0.04)

0.006 (0.07)

0.17

0.48 (0.15)

Medial prefrontal

0.19 (0.05)

−0.07 (0.05)

0.12

0.38 (0.11)

Occipital

0.2 (0.05)

−0.01 (0.05)

0.19

0.39 (0.12)

Orbitofrontal

0.24 (0.04)

−0.06 (0.05)

0.18

0.48 (0.14)

Dorsolateral prefrontal

0.15 (0.04)

−0.01 (0.06)

0.14

0.43 (0.13)

(D) ADNI lumbar puncture cohort

 

Amyloid-PET main effect β estimate (SE)

Single APOE4 main effect β estimate (SE)

Total of amyloid-PET main effect β estimate and single APOE4 main effect β estimate

Amyloid-PET × Single APOE4 interaction effect β estimate (SE)

CSF p-tau

14.81 (3.53)

3.94 (1.28)

18.75

20.31 (6.59)

(E) ADNI lumbar puncture cohort

 

Amyloid-PET main effect β estimate (SE)

Double APOE4 main effect β estimate (SE)

Total of amyloid-PET main effect β estimate and double APOE4 main effect β estimate

Amyloid-PET × Double APOE4 interaction effect β estimate (SE)

CSF p-tau

14.81 (3.53)

3.87 (2.55)

18.68

33.01 (14.24)

  1. It reports beta coefficients for main and interactive effects of amyloid-PET and APOEε4 on tau. A–C: beta coefficients from brain regions where a significant synergistic effect of amyloid-PET and APOEε4 on tau-PET was observed. D, E: Beta coefficients from global neocortical amyloid-PET and APOEε4 on CSF p-tau. Standard errors are reported in parentheses. The amyloid-PET and APOEε4 interaction effect estimate is greater than the sum of the individual main effects, indicating the presence of a synergistic interaction. Standard errors are reported in parentheses.
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