Fig. 1: Flowchart of analyses and datasets used.

Six independent cohorts were assessed. These included the discovery sample, three replication cohorts, and two post-mortem brain cohorts. AUD alcohol use disorder, FDR false discovery rate, GS Generation Scotland: Scottish Family Health Study, GTP Grady Trauma Project, WCGNA weighted genome coregulation network analysis, BOLD blood oxygen level-dependent, fMRI functional magnetic resonance imaging, MRI magnetic resonance imaging, GAS5 growth arrest specific 5, FKBP5 FK506-binding protein 5.