Table 1 Non-imaging characteristics, the total analysis sample and the developmental change subsample at their baseline assessment.

From: Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study

Variable

Analysis sample

(N = 1476)

Developmental change subsample

(N = 714)

Youth demographic and anthropometric features

  Sex (female)

819 (55%)

445 (62%)

  Age (years)

14.45 (0.40)

14.45 (0.41)

  Height (cm)

167.37 (7.86)

167.32 (7.81)

  Weight (kg)

58.23 (10.92)

57.58 (10.29)

  Body mass index

20.72 (3.24)

20.5 (2.99)

  Pubertal Development Scale

13.07 (2.22)

13.2 (2.2)

Youth perinatal events

  Birth weight (g)

3424 (563)

3419 (553)

  Maternal smoking during pregnancy

178 (15%)

76 (12%)

  Paternal smoking during pregnancy

250 (21%)

108 (18%)

  Maternal alcohol use during pregnancy

269 (22%)

142 (23%)

  Maternal medical illness during pregnancy

91 (7%)

51 (8%)

  Pregnancy and/or birth complications

230 (19%)

117 (19%)

  Breastfed

1032 (84%)

535 (86%)

Youth mental health

  Presence of psychiatric diagnosis

192 (13%)

79 (11%)

Youth cognitive ability

  General intelligence g-factor (z score)

0.02 (0.97)

0.17 (0.88)

 ESPAD: Average grade

  • 1: C−

12 (1%)

2 (0.3%)

  • 2: C

28 (2%)

10 (2%)

  • 3: C+

40 (3%)

17 (3%)

  • 4: B−

48 (4%)

18 (3%)

  • 5: B

131 (10%)

59 (9%)

  • 6: B+

408 (32%)

178 (29%)

  • 7: A−

444 (35%)

244 (39%)

  • 8: A

150 (12%)

92 (15%)

 ESPAD: Truancy

4.13 (1.56)

3.99 (1.69)

Youth personality and temperament

  NEO: Neuroticism

1.88 (0.58)

1.91 (0.57)

  NEO: Extroversion

2.45 (0.43)

2.43 (0.44)

  NEO: Openness

2.2(0.47)

2.24 (0.49)

  NEO: Agreeableness

2.33 (0.4)

2.38 (0.4)

  NEO: Conscientiousness

2.3(0.55)

2.36 (0.56)

  DAWBA Social Aptitude Scale

24.43 (5.79)

24.61 (5.6)

  TCI: Novelty seeking

111.22 (10.42)

110.63 (10.47)

Youth substance risk and use

  SURPS: Anxiety sensitivity

2.25 (0.46)

2.26 (0.46)

  SURPS: Hopelessness

1.87 (0.41)

1.87 (0.42)

  SURPS: Impulsivity

2.43 (0.44)

2.39 (0.44)

  SURPS: Sensation seeking

2.77 (0.55)

2.74 (0.54)

 ESPAD: Frequency of lifetime smoking

  • 0: Never

875 (69%)

459 (74%)

  • 1: 1–2 times

178 (14%)

86 (14%)

  • 2: 3–5 times

52 (4%)

19 (3%)

  • 3: 6–9 times

40 (3%)

15 (2%)

  • 4: 10–19 times

38 (3%)

16 (3%)

  • 5: 20–39 times

18 (1%)

10 (2%)

  • 6: 40 or more times

60 (5%)

15 (2%)

 ESPAD: Smoking in the preceding 30 days

  • 0: Not at all

1127 (89%)

571 (92%)

  • 1: less than 1 cigarette per week

56 (4%)

26 (4%)

  • 2: less than 1 cigarette per day

28 (2%)

9 (1%)

  • 3: 1–5 cigarettes per day

32 (2%)

8 (1%)

  • 4: 6–10 cigarettes per day

9 (1%)

3 (0.5%)

  • 5: 11–20 cigarettes per day

6 (0.5%)

3 (0.5%)

  • 6: more than 20 cigarettes per day

3 (0.2%)

0 (0%)

 ESPAD: Frequency of lifetime alcohol use

  • 0: Never

285 (23%)

135 (22%)

  • 1: 1–2 times

324 (26%)

161 (26%)

  • 2: 3–5 times

239 (19%)

127 (21%)

  • 3: 6–9 times

173 (14%)

86 (14%)

  • 4: 10–19 times

132 (10%)

68 (11%)

  • 5: 20–39 times

64 (5%)

24 (4%)

  • 6: 40 or more times

41 (3%)

17 (3%)

 ESPAD: Frequency of alcohol use in the preceding 30 days

  • 0: Not at all

638 (51%)

325 (53%)

  • 1–2 times

452 (36%)

218 (35%)

  • 3–5 times

104 (8%)

46 (7%)

  • 6–9 times

36 (3%)

16 (3%)

  • 10–19 times

19 (1%)

10 (2%)

  • 20–39 times

6 (0.5%)

2 (0.3%)

  • 40 or more times

3 (0.2%)

1 (0.2%)

 ESPAD: Frequency of lifetime cannabis use

  • 0: Never

1180 (94%)

592 (96%)

  • 1: 1–2 times

41 (3%)

16 (3%)

  • 2: 3–5 times

9 (1%)

3 (0.5%)

  • 3: 6–9 times

8 (1%)

2 (0.3%)

  • 4: 10–19 times

5 (0.3%)

0 (0%)

  • 5: 20–39 times

1 (0.1%)

0 (0%)

  • 6: 40 or more times

10 (1%)

3 (0.5%)

 ESPAD: Frequency of cannabis use in the preceding 30 days

  • 0: 0

1211 (96%)

603 (98%)

  • 1: 1–2 times

30 (2%)

11 (2%)

  • 2: 3–5 times

2 (0.2%)

0 (0%)

  • 3: 6–9 times

4 (0.3%)

0 (0%)

  • 4: 10–19 times

3 (0.2%)

0 (0%)

  • 5: 20–39 times

1 (0.1%)

0 (0%)

  • 6: 40 or more times

3 (0.2%)

2 (0.3%)

Youth social and family circumstances

 LEQ: Total number of negative life events since last visit

5.83 (2.96)

5.66 (3.03)

 LEQ: Family-related life events since last visit

0.26 (0.23)

0.24 (0.22)

 LEQ: Family accidents or illness since last visit

0.53 (0.27)

0.51 (0.27)

 LEQ: Events relating to sexuality/intimacy since last visit

0.29 (0.18)

0.28 (0.18)

 LEQ: Autonomy: events relating to independence since last visit

0.53 (0.18)

0.53 (0.17)

 LEQ: Deviance: events relating to legal or school problems

0.27 (0.23)

0.24 (0.23)

 LEQ: Relocation: events relating to change in schools or residence since last visit

0.45 (0.33)

0.45 (0.33)

 LEQ: Distress: distressing events since last visit

0.29 (0.19)

0.28 (0.19)

 LEQ: Other events since last visit

0.33 (0.27)

0.34 (0.28)

 ESPAD: Victim of bullying

0.19 (0.39)

0.2 (0.4)

 ESPAD: Perpetrator of bullying

0.1 (0.3)

0.07 (0.26)

 DAWBA: Family stressors: Financial/housing

0.72 (1.08)

0.65 (1.03)

 DAWBA: Family stressors: Work pressure

1.07 (1.08)

1.11 (1.09)

 DAWBA: Family stressors: Illness

0.52 (0.9)

0.51 (0.9)

 DAWBA: Family stressors: Relationships/addiction

0.42 (0.74)

0.39 (0.73) 

 DAWBA: Child experience: Affirmation

10.82 (1.47)

10.9 (1.35)

 DAWBA: Child experience: Discipline

3.43 (1.58)

3.35 (1.58)

 DAWBA: Child experience: Rules

4.64 (1.24)

4.64 (1.27)

 DAWBA: Living with both parents

1267 (86%)

620 (87%)

 FIGS: Positive family history of psychiatric disorders

274 (19%)

129 (18%)

Parental characteristics

  ESPAD: Maternal education level

  • GCSEs or CSEs or below

235 (17%)

90 (13%)

  • NVQ or GNVQ

273 (19%)

112 (16%)

  • A levels or a BTEC national diploma

204 (15%)

111 (16%)

  • Advanced diploma

203 (14%)

100 (15%)

  • Bachelor degree

321 (23%)

175 (26%)

  • Professional qualification (Master’s degree and above)

162 (11%)

91 (13%)

 ESPAD: Paternal education level

  • GCSEs or CSEs or below

300 (21%)

113 (17%)

  • GNVQ or NVQ

209 (15%)

109 (16%)

  • A levels or a BTEC national diploma

175 (12%)

86 (13%)

  • Advanced diploma

164 (12%)

78 (12%)

  • Bachelor degree

313 (22%)

168 (25%)

  • Professional qualification (Master’s degree and above)

237 (17%)

125 (18%)

  1. Continuous variables are shown as mean (standard deviation); categorical variables are shown as number (percentage, %). Details of each variable are shown in Supplementary Table S2.
  2. ESPAD European School Survey Project on Alcohol and Other Drugs, DAWBA Development and Well-being Assessment, FIGS Family Interview for Genetic Studies, LEQ Life Events Questionnaire, NEO NEO-Five Factor Personality Inventory, SURPS Substance Use Risk Profile Scale, TCI Temperament and Character Inventory, WISC-IV Wechsler Intelligence Scale for Children-IV, GCSE General Certificate of Secondary Education, CSE Certificate of Secondary Education, GNVC General National Vocational Qualification, NVQ National Vocational Qualification, BTEC Business and Technology Education Council, A levels Advanced Level Qualification.