Table 1 FDR-corrected significant results for group differences between obese and normal weight subjects as assessed using separate linear regression models with a dichotomous group predictor (obesity versus normal weight).

From: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders

Label	Estimate	Std error	T	p	FDR adjusted p	Cohen´s d	N Obese	N NW
Global measures
Left hemispheral average thickness	−0.021	0.003	−6.23	5.18E−10	<0.0001	−0.214	1200	2865
Right hemispheral average thickness	−0.020	0.003	−5.89	4.18E−09	<0.0001	−0.203	1200	2865
Total Intracranial Volume	−21634.000	5603.000	−3.86	1.10E−04	0.0005	−0.135	1168	2755
Total right hemispheral surface area	−708.380	258.090	−2.74	6.08E−03	0.0165	−0.095	1189	2872
Total left hemispheral surface area	−654.300	256.890	−2.55	1.09E−02	0.0281	−0.088	1189	2872
Cortical thickness
Left fusiform gyrus	−0.051	0.005	−9.59	2.00E−16	<0.0001	−0.331	1195	2849
Right fusiform gyrus	−0.050	0.005	−9.42	2.00E−16	<0.0001	−0.325	1193	2849
Right superior temporal gyrus	−0.041	0.006	−7.17	9.09E−13	<0.0001	−0.251	1161	2745
Left superior temporal gyrus	−0.040	0.006	−6.88	7.04E−12	<0.0001	−0.243	1138	2684
Left inferior temporal gyrus	−0.040	0.006	−6.62	4.17E−11	<0.0001	−0.231	1165	2823
Left middle temporal gyrus	−0.039	0.006	−6.46	1.18E−10	<0.0001	−0.227	1149	2748
Right middle temporal gyrus	−0.036	0.006	−6.06	1.49E−09	<0.0001	−0.210	1184	2815
Right pars opercularis	−0.033	0.006	−5.96	2.70E−09	<0.0001	−0.206	1189	2835
Right posterior cingulate cortex	−0.033	0.006	−5.96	2.71E−09	<0.0001	−0.205	1196	2859
Right inferior temporal gyrus	−0.036	0.006	−5.88	4.54E−09	<0.0001	−0.204	1175	2838
Left precentral gyrus	−0.030	0.005	−5.85	5.27E−09	<0.0001	−0.202	1192	2837
Right precentral gyrus	−0.030	0.005	−5.76	9.13E−09	<0.0001	−0.199	1188	2844
Right superior frontal gyrus	−0.030	0.005	−5.76	8.93E−09	<0.0001	−0.199	1189	2859
Left transverse temporal gyrus	−0.042	0.008	−5.29	1.26E−07	<0.0001	−0.182	1195	2853
Left insula	−0.030	0.006	−5.17	2.41E−07	<0.0001	−0.179	1188	2811
Left posterior cingulate cortex	−0.030	0.006	−5.16	2.56E−07	<0.0001	−0.178	1196	2857
Right medial orbitofrontal cortex	−0.031	0.006	−5.12	3.18E−07	<0.0001	−0.177	1183	2831
Left banks of the superior temporal sulcus	−0.031	0.006	−4.88	1.08E−06	<0.0001	−0.172	1139	2708
Left caudal middle frontal gyrus	−0.026	0.005	−4.89	1.04E−06	<0.0001	−0.169	1196	2840
Right banks of the superior temporal sulcus	−0.030	0.006	−4.63	3.81E−06	<0.0001	−0.161	1178	2796
Left entorhinal cortex	−0.061	0.013	−4.5	6.86E−06	<0.0001	−0.158	1164	2725
Left paracentral lobule	−0.024	0.005	−4.46	8.55E−06	<0.0001	−0.154	1195	2857
Right parahippocampal gyrus	−0.044	0.010	−4.46	8.50E−06	<0.0001	−0.154	1192	2850
Left temporal pole	−0.059	0.014	−4.38	1.20E−05	0.0001	−0.151	1187	2851
Left superior frontal gyrus	−0.023	0.005	−4.35	1.36E−05	0.0001	−0.150	1194	2851
Left supramarginal gyrus	−0.021	0.005	−4.15	3.45E−05	0.0002	−0.145	1173	2767
Right precuneus	−0.019	0.005	−4.13	3.75E−05	0.0002	−0.142	1195	2848
Left pars opercularis	−0.021	0.005	−4.03	5.58E−05	0.0003	−0.139	1194	2845
Right paracentral lobule	−0.022	0.005	−3.94	8.38E−05	0.0004	−0.136	1196	2857
Right caudal middle frontal gyrus	−0.020	0.005	−3.73	2.00E−04	0.0008	−0.129	1194	2845
Left isthmus cingulate cortex	−0.026	0.007	−3.7	2.20E−04	0.0009	−0.128	1195	2852
Right lateral orbitofrontal cortex	−0.022	0.006	−3.68	2.40E−04	0.0009	−0.127	1195	2858
Left precuneus	−0.017	0.005	−3.66	2.60E−04	0.0010	−0.126	1189	2851
Right temporal pole	−0.050	0.014	−3.58	3.40E−04	0.0012	−0.124	1191	2850
Left lateral orbitofrontal cortex	−0.021	0.006	−3.56	3.70E−04	0.0013	−0.123	1188	2851
Right rostral middle frontal gyrus	−0.017	0.005	−3.53	4.10E−04	0.0014	−0.122	1192	2849
Left inferior parietal cortex	−0.017	0.005	−3.5	4.80E−04	0.0016	−0.121	1180	2831
Right insula	−0.022	0.006	−3.46	5.40E−04	0.0018	−0.120	1182	2777
Right pars triangularis	−0.020	0.006	−3.39	7.20E−04	0.0023	−0.117	1187	2838
Right isthmus cingulate cortex	−0.022	0.007	−3.18	1.50E−03	0.0045	−0.110	1196	2854
Right supramarginal gyrus	−0.016	0.005	−3.18	1.50E−03	0.0045	−0.111	1178	2780
Left parahippocampal gyrus	−0.035	0.011	−3.08	2.08E−03	0.0060	−0.106	1190	2850
Right transverse temporal gyrus	−0.025	0.008	−3.05	2.30E−03	0.0066	−0.105	1190	2849
Left rostral middle frontal gyrus	−0.014	0.005	−2.8	5.10E−03	0.0140	−0.097	1197	2848
Left rostral anterior cingulate cortex	−0.023	0.009	−2.74	6.20E−03	0.0165	−0.095	1189	2835
Left medial orbitofrontal cortex	−0.015	0.006	−2.51	1.22E−02	0.0309	−0.087	1182	2818
Left frontal pole	−0.028	0.011	−2.49	1.28E−2	0.0313	−0.086	1199	2863
Right pars orbitalis	−0.020	0.008	−2.5	1.26E−02	0.0313	−0.086	1198	2848
Left superior parietal cortex	−0.010	0.004	−2.44	1.50E−02	0.0350	−0.084	1187	2831
Left pars orbitalis	−0.019	0.008	−2.31	2.11E−02	0.0473	−0.080	1194	2854
Cortical surface area
Left isthmus cingulate cortex	25.900	5.492	4.72	2.50E−06	<0.0001	0.167	1134	2700
Right isthmus cingulate cortex	21.160	5.097	4.15	3.37E−05	0.0002	0.147	1137	2706
Left transverse temporal gyrus	10.183	2.603	3.91	9.32E−05	0.0004	0.138	1141	2708
Right rostral middle frontal gyrus	−71.936	22.908	−3.14	1.70E−03	0.0050	−0.111	1135	2698
Right paracentral lobule	21.589	7.403	2.92	3.57E−03	0.0100	0.104	1117	2688
Left inferior temporal gyrus	−40.910	15.209	−2.69	7.18E−03	0.0188	−0.096	1099	2673
Right inferior temporal gyrus	−35.140	14.136	−2.49	1.30E−02	0.0313	−0.089	1115	2684
Left paracentral lobule	16.023	6.589	2.43	1.51E−02	0.0350	0.087	1099	2658
Left lingual gyrus	−32.434	13.793	−2.35	1.88E−02	0.0428	−0.083	1128	2692
Subcortical volume
Right amygdala	41.656	6.984	5.96	2.68E−09	<0.0001	0.211	1129	2702
Left thalamus	108.695	26.117	4.16	3.23E−05	0.0002	0.147	1138	2691
Right thalamus	80.814	22.216	3.64	2.80E−04	0.0010	0.129	1134	2680
Left amygdala	22.444	6.474	3.47	5.30E−04	0.0018	0.123	1127	2694
Left nucleus accumbens	11.724	3.541	3.31	9.40E−04	0.0030	0.118	1110	2660
Right hippocampus	33.557	13.810	2.43	1.52E−02	0.0350	0.086	1136	2709

Results are displayed for global measures, cortical thickness, and surface area as well as for subcortical volumes and sorted by p value within each domain. All results are adjusted for age, sex, MDD diagnosis, and site. Regional surface and subcortical results are adjusted for total intracranial volume.
Estimate regression estimate, StdError standard error, T t-value, p uncorrected p value, FDR adjusted p FDR adjusted p value, N Obese number of obese subjects included in analysis, N NW number of normal weight subjects included in analysis.

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Table 1 FDR-corrected significant results for group differences between obese and normal weight subjects as assessed using separate linear regression models with a dichotomous group predictor (obesity versus normal weight).

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