Table 2 Regional [11C](R)-PK11195 BPND in antipsychotic-free recent onset schizophrenia patients compared with age- and sex-matched healthy controls.

From: Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis

 

Controls (n = 10)

Antipsychotic-free patients (n = 6)

Controls vs Antipsychotic-free

Region

BPND

BPND

Difference (%)

Cohen’s d

ACC

0.086 ± 0.038

0.036 ± 0.073

−58

0.86

PFC

0.058 ± 0.042

0.024 ± 0.071

−59

0.58

OFC

0.039 ± 0.035

0.0003 ± 0.064

−99

0.75

Parietal

0.044 ± 0.041

0.020 ± 0.052

−55

0.51

Putamen

0.075 ± 0.047

0.018 ± 0.042

−76

1.28

Thalamus

0.196 ± 0.063

0.144 ± 0.077

−27

0.74

Brainstem

0.142 ± 0.061

0.097 ± 0.058

−32

0.76

Mean all ROIs

0.092 ± 0.030

0.048 ± 0.046

−48

1.13

  1. BPND values are presented as mean ± SD.
  2. BPND binding potential, ROI region of interest, ACC anterior cingulate cortex, PFC prefrontal cortex, OFC orbitofrontal cortex.
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