Fig. 2: Gene-expression patterns of WT and Psen1KI/KI microglia.
From: Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
RNA sequencing performed in adult microglia from WT and Psen1KI/KI mouse. a Schematic diagram showing the strategy used to profile microglial transcripts. b Expression (Counts per million, CPM) of WT plotted against CPM Psen1KI/KI microglia. c Principal component analysis restricted to microglia identity genes expressed in WT or Psen1KI/KI adult microglia (upper panel) or all genes (lower panel). d, e Biological pathways terms enriched in genes differentially expressed in Psen1KI/KI microglia compared to WT microglia identified by Ingenuity Pathway Analysis (IPA). N = 4 mice per group.
