Fig. 3: RU486 induced early brain NFκB activation and corresponding depressive-like behavior. | Molecular Psychiatry

Fig. 3: RU486 induced early brain NFκB activation and corresponding depressive-like behavior.

From: Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior

Fig. 3

a Schematic illustrating repeated analysis with single-monitoring in IL-PFC. b Individual GR profiles of 1 mg/kg LPS (left panel) and 10 mg/kg RU486 + 1 mg/kg LPS (right panel). c Individual NFκB profiles of 1 mg/kg LPS (left panel) and 10 mg/kg RU486 + 1 mg/kg LPS (right panel). The orange line represents the average GR activity at each time point (n = 12). Time course of behavior for (d) immobility time in the FST. Data are represented as the mean ± standard error of measurement [n = 8/group, except for 12 h post-LPS (n = 7/group)] (e) the trajectories of NFκB and GR activities in the LPS/RU486-treated mice. Statistical significance was determined by Student’s t-test (*P < 0.05 vs control). IL-PFC infralimbic prefrontal cortex, LPS lipopolysaccharide, FST forced swimming test, Dep depressive-like behavior (color figure online).

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