Table 2 Diagnostic parameters for plasma tau and NfL in sCJD, derived from Receiver Operating Characteristic (ROC) analysis.
sCJD… | vs Healthy controls | vs All non-prion disease | vs ‘CJD mimics’ | |||
|---|---|---|---|---|---|---|
Plasma biomarker | tau | NfL | tau | NfL | tau | NfL |
Area under ROC curve | 0.913 | 1.0 | 0.808 | 0.912 | 0.809 | 0.724 |
Cut-off (pg/mL) (Youden method) | >3.27 | >25.87 | >6.11 | >60.65 | >3.81 | >60.65 |
Sensitivity (95% C.I.) | 80% (73–87%) | 100% (n/a) | 57% (42–73%) | 93% (89–97%) | 74% (59–88%) | 93% (88–98%) |
Specificity (95% C.I.) | 97% (90–100%) | 100% (n/a) | 95% (82–100%) | 84% (75–93%) | 83% (68–99%) | 57% (39–74%) |
