Table 1 SNP-based heritability (SNP-h2) of treatment-resistant depression (TRD) and non-TRD compared with healthy controls in UKB.

From: Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

Method

TRD SNP-h2

Non-TRD SNP-h2

Low prevalence

K = 0.01

Estimated prevalence

K = 0.023

High prevalence

K = 0.03

Low prevalence

K = 0.08

Estimated prevalence

K = 0.085

High prevalence

K = 0.10

GCTA

0.2660 (0.0412)

0.3306 (0.0512)

0.3581 (0.0555)

0.2495 (0.0238)

0.2563 (0.0245)

0.2765 (0.0264)

GCTB

0.1979 (0.0333)

0.2459 (0.0414)

0.2664 (0.0449)

0.1877 (0.0185)

0.1928 (0.0190)

0.2079 (0.0205)

LDSC

0.1748 (0.0271)

0.2173 (0.0337)

0.2354 (0.0365)

0.1877 (0.0174)

0.1928 (0.0178)

0.2080 (0.0193)

  1. SNP-h2 was reported according to different possible values of prevalence (K) in the population; the most plausible values are reported in bold. GCTA genome-wide complex trait analysis, GCTB Genome-wide Complex Trait Bayesian, LDSC linkage-disequilibrium score regression.
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