Fig. 2: Ketamine decreases tuning of single neurons for remembered locations.

a Firing rate of an example neuron for a ketamine-WM session. On the left, spike density functions (SDFs) over the pre-cue interval (gray column), cue, delay (yellow), and response epochs. Preferred locations and least-preferred locations are bolded. Center, firing rates during the delay epoch for all target locations. Right, firing rates fitted to a polynomial plane. b Firing rate of a second example neuron during a ketamine-WM session. c Average proportion of tuned single units during the cue epoch (pink), delay epoch (orange), or during both (purple) for each injection period for ketamine-WM sessions. d Average proportion of tuned single units during each epoch for saline-WM sessions. e Example session indicating firing rate averaged over neurons for target locations ranked from preferred to least-preferred locations. Black lines represent slope. f Fitted slope for each injection period averaged over sessions. g Firing rate for each target location ranked and averaged over sessions for each injection period. All error bars are SEM. *<0.05, **<0.01, ***<0.001. Red center lines indicate median, the bottom and top edges of the box indicate the 25th and 75th percentiles. The whiskers extend to non-outlier data points (approximately within 2.7 std) and the outliers are plotted using ‘+’.