Fig. 2: IL-1β activation in Grk3−/− mice.
From: GRK3 deficiency elicits brain immune activation and psychosis
A Increased levels of IL-1β are detected in hippocampus of Grk3−/− mice (n = 5) compared to Grk3−/− mice (n = 5; P = 0.0079). B In wildtype mice (vehicle control: n = 8, and n = 9 IL-1β administered mice), ICV administration of IL-1β (0.5 ng) significantly increased hippocampal KYNA levels (P = 0.027), and (C) induced PPI deficits (P = 0.027; vehicle control n = 8, and n = 9 IL-1β administered mice). Group comparisons in (A) and (B) were performed using Mann–Whitney U tests. Group comparisons in (C) were performed using unpaired t test with Welch’s correction. All error bars represent SEM. All tests were two-tailed. *P < 0.05, and **P < 0.01.
