Table 1 Top differentially expressed proteins (relative to Ctrls) detected via TMT-LC/MS.

From: Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids

Short protein name

Long protein name

Uniprot accession

ANOVA p value

NDUFAF2

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex Assembly Factor 2

Q8N183

0.000481025

TMEM50B

Transmembrane Protein 50B

P56557

0.000548505

IMPA1

Inositol Monophosphatase 1

P29218

0.001902383

ARMCX1

Armadillo Repeat-Containing X-Linked Protein 1

Q9P291

0.002196252

GBF1

Golgi-Specific Brefeldin A-Resistance Guanine Nucleotide Exchange Factor 1

Q92538-3

0.002520107

HDHD5

Haloacid Dehalogenase-Like Hydrolase Domain-Containing 5

Q9BXW7-2

0.00307041

GTPBP4

Nucleolar GTP-Binding Protein 1

Q9BZE4

0.00324609

ARF4

ADP-Ribosylation Factor 4

P18085

0.003766362

GRPEL1

GrpE Protein Homolog 1, Mitochondrial

Q9HAV7

0.004413199

ACAT2

Acetyl-CoA Acetyltransferase, Cytosolic

Q9BWD1

0.004730022

MANF

Mesencephalic Astrocyte-Derived Neurotrophic Factor

P55145

0.005179981

DOCK4

Dedicator of Cytokinesis Protein 4

Q8N1I0–2

0.00538423

TXNRD1

Thioredoxin-Disulfide Reductase

E9PIR7

0.005572821

DIABLO

Diablo Homolog, Mitochondrial

Q9NR28-2

0.00627476

HSPA13

Heat Shock 70 kDa Protein 13

P48723

0.00627476

TFCP2

Alpha-Globin Transcription Factor CP2

Q12800-2

0.00639284

DYNLT1

Dynein Light Chain Tctex-Type 1

P63172

0.00671083

HDGF

Hepatoma-Derived Growth Factor

P51858

0.007032222

PSMB7

Proteasome Subunit Beta Type-7

Q99436

0.007289525

UNK

RING Finger Protein Unkempt Homolog

Q9C0B0

0.008045913

HYOU1

Hypoxia Up-Regulated Protein 1

Q9Y4L1

0.008687815

SEC62

Translocation Protein SEC62

Q99442

0.010325685

APLP2

Amyloid-Like Protein 2

Q06481-4

0.013408141

USP7

Ubiquitin Carboxyl-Terminal Hydrolase 7

Q93009-3

0.015504379

KATNAL1

Katanin p60 ATPase-Containing Subunit A-Like 1

Q9BW62

0.015622147

HSPA5

Endoplasmic Reticulum Chaperone BiP

P11021

0.015742232

DYNC1LI1

Cytoplasmic Dynein 1 Light Intermediate Chain 1

Q9Y6G9

0.016475164

ABCF1

ATP-Binding Cassette Sub-Family F Member 1

Q8NE71-2

0.016611257

SHMT2

Serine Hydroxymethyltransferase, Mitochondrial

P34897-3

0.018482781

DHTKD1

Probable 2-Oxoglutarate Dehydrogenase E1 Component DHKTD1, Mitochonondrial

Q96HY7

0.018748869

SLC7A1

High Affinity Cationic Amino Acid Transporter 1

P30825

0.021172737

PIK3C2B

Phosphatidylinositol 4-Phosphate 3-Kinase C2 Domain-Containing Subunit Beta

O00750

0.021899148

SORBS1

Sorbin and SH3 Domain-Containing Protein 1

Q9BX66-4

0.024998617

HSPA9

Stress-70 Protein, Mitochondrial

P38646

0.027136132

CCDC47

Coiled-Coil domain-Containing Protein 47

Q96A33

0.028644274

ALG2

Alpha-1,3/1,6-Mannosyltransferase ALG2

Q9H553

0.030668953

APP

Amyloid-Beta Precursor Protein

P05067-11

0.031024857

SUPT6H

Transcription Elongation Factor SPT6

Q7KZ85

0.033263913

RRP12

RRP12-Like Protein

Q5JTH9-2

0.033924326

MLF2

Myeloid Leukemia Factor 2

Q15773

0.043882525

RPS13

40 s Ribosomal Protein S13

P62277

0.047438594

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