Table 4 Differentially expressed metabolites in human enviromimetic organoids.

	Enviromimetic drug/Risk factor treatment group
	WIN	IL17a	CORT	Nicotine	Ethanol	Endomorphin
3-Phosphoglyceric Acid		↓	↓
Acetylcysteine				↓
Allantoin		↓		↓
Creatinine		↓	↓	↓	↓
D-Ribose 5-Phosphate				↓
Guanosine Monophosphate					↓
Guanosine Triphosphate		↑	↑	↑	↑	↑
Inosine					↓
L-Leucine		↓	↓		↓
L-Methionine		↓	↓	↓	↓	↓
L-Phenylalanine	↓	↓	↓	↓	↓	↓
L-Tyrosine	↓	↓	↓	↓	↓
L-Valine	↓	↓		↓	↓
N-Acetylglutamine			↓
N-Acetylornithine		↓	↓		↓
Pyruvic Acid		↓
S-Adenosylhomocysteine			↓	↓
Succinic Acid					↓

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