Fig. 1: Basic CSF characteristics are in accordance with expectations for F2x patients and controls.

A Illustration of study design B Basic CSF characteristics: cells were counted manually in a Fuchs-Rosenthal chamber; protein was assessed by nephelometry; BBBD was evaluated based on the serum/CSF albumin ratio; Ig synthesis was assessed by nephelometry; oligoclonal bands were detected by isoelectric focusing and silver nitrate staining. Box plots show the lower quartile, median and upper quartile. Whiskers depict 1.5 times the interquartile range of the box and outliers are illustrated by dots. Significance was calculated with the Kruskal Wallis test and post hoc two-sided Dunn test if the dependent variable was continuous. Fisher test was carried out for categorical dependent variables. P values were adjusted for multiple hypothesis testing with Benjamini-Hochberg’s procedure. (BBBD: blood-brain-barrier dysfunction; CSF: cerebrospinal fluid; F2x: patients with psychotic disorder, Ig: immunoglobulin; IIH: intracranial hypertension; NMDARE: anti-NMDA-receptor encephalitis; ocb: oligoclonal band; RRMS: Relapsing-Remitting Multiple Sclerosis).