Fig. 6: MALDI MS images showing the distribution of risperidone and its metabolite, hydroxyl risperidone, in a representative brain tissue sample with a lateral resolution of 20 µm. | Molecular Psychiatry

Fig. 6: MALDI MS images showing the distribution of risperidone and its metabolite, hydroxyl risperidone, in a representative brain tissue sample with a lateral resolution of 20 µm.

From: Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Fig. 6

a, b Structural morphology was correlated with hematoxylin and eosin-stained brain tissue after MALDI-MSI analysis. c, d Ion distribution of risperidone in the brain tissue section. e, f Ion distribution of hydroxyl risperidone in the brain tissue section. Ion intensities are normalized against that for the ion of the deuterated analog of risperidone; absolute ion intensities are shown using a rainbow color code scaled to a linear scale ranging from 0 to 5. Scale bar: 500 µm. CPu caudate putamen, NAc nucleus accumbens, LS lateral septum, cc corpus callosum, ec external capsule, aca anterior commissure, LV lateral ventricle, E ependymal and subependymal layers of lateral ventricle.

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